By Joseph W. St. Geme III
This booklet describes the turning out to be physique of data at the epidemiology, scientific manifestations, transmission, pathogenesis, analysis, and remedy of Kingella kingae infectionsin childrens. furthermore, it covers experimental equipment which have been constructed to check the microbiology, genetics, and virulence elements of K. kingae, info that gives the basis for brand spanking new techniques to remedy and prevention of K. kingae disease. With this content material in brain, excerpts from the e-book should be of relevance for clinicians who take care of pediatric sufferers, for medical microbiologists who're concerned about detecting organisms in medical specimens, and for scientists who're learning K. kingae in an attempt to increase novel pursuits for antimicrobial treatment and new techniques to prevention.
First remoted within the Sixties by way of Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae used to be principally missed over the subsequent 20 years as a human pathogen as a result of its unusual restoration from sufferers with illness. despite the fact that, lately K. kingae has been more and more well-known as a clinically vital pathogen in teenagers, and is presently well-known because the major reason behind osteoarticular infections in childrens in increasingly more international locations. learn into this organism has grown significantly over the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of affliction.
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This ebook describes the turning out to be physique of data at the epidemiology, scientific manifestations, transmission, pathogenesis, prognosis, and remedy of Kingella kingae infectionsin little ones. furthermore, it covers experimental equipment which were built to check the microbiology, genetics, and virulence components of ok.
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Additional info for Advances in Understanding Kingella kingae
Geme JW 3rd (2009) Expression of Kingella kingae type IV pili is regulated by sigma54, PilS, and PilR. J Bacteriol 191(15):4976–4986. doi:10. 00123-09 54. Slonim A, Steiner M, Yagupsky P (2003) Immune response to invasive Kingella kingae infections, age-related incidence of disease, and levels of antibody to outer-membrane proteins. Clin Infect Dis 37(4):521–527. 1086/376913 55. Dubnov-Raz G, Ephros M, Garty BZ, Schlesinger Y, Maayan-Metzger A, Hasson J, Kassis I, Schwartz-Harari O, Yagupsky P (2010) Invasive pediatric Kingella kingae Infections: a nationwide collaborative study.
In the longitudinal study by Amit et al. 1 % of children were colonized at least twice. Among the children with K. kingae isolated on multiple visits, 90 % of strains isolated within 2 months of one another were genetically similar, whereas only 22 % of isolates identiﬁed greater than 5 months apart were genetically similar. These data demonstrate that carriage of speciﬁc strains is relatively transient in healthy children, lasting weeks to months. Strains that colonize the oropharynx may be replaced, and long-term carriage by a speciﬁc strain is rare.
While some children had short, intermittent carriage, others had repeatedly positive cultures over weeks or months. Nearly 75 % of children in this cohort carried K. kingae at least once, and half of all children carried the organism two or more times. Slonim et al.  assessed the genetic relatedness of 50 K. kingae strains isolated from this same population and found that individual children often carried speciﬁc strains continuously or intermittently for weeks or months until the strains were replaced by new ones.
Advances in Understanding Kingella kingae by Joseph W. St. Geme III